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Adenomatous nodule in Cowden syndrome (PHTS): Cowden syndrome is the principal PTEN-related disorder, which are genodermatosis characterized by multiple mucosal papillomatosis, and facial trichilemmomas and with a high risk for benign and malignant tumors of the thyroid, breast, and endometrium. PTEN immunostaining showing complete loss of immunoreactivity for PTEN of the follicular cells in one nodule. The endothelial cells and the adjacent thyroid follicular cells are positive
