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. 2022 Apr 19;13(4):373. doi: 10.1038/s41419-022-04827-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A An overview of the correlations between xCT expression, mRNAsi, and known clinical characteristics (TNM stage, sex, and survival status) in the TCGA-COAD cohort. B The association between the expression of xCT and mRNAsi in the TCGA-COAD cohort. C, D Western blot assay was applied to detect the expression of xCT in CRC cells and CRC stem cells. E, F Sphere formation assays showed that xCT inhibition suppressed the sphere-forming capability of CRC stem cells. G, H Western blot analysis showed that xCT knockdown reduced the expression level of stemness-related molecules in HCT116 cells and HCT15 cells. I, J Flow cytometry indicated that xCT inhibition significantly diminished the expression of EPCAM and CD133 in CRC cells. K, L IF staining showed that xCT knockdown suppressed the expression of CD133 in CRC cells. **P < 0.01.