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. 2022 Apr 19;13(4):373. doi: 10.1038/s41419-022-04827-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A xCT knockdown inhibited the growth of tumors in CRC xenograft mouse models. Differences in tumor weight (B) and volume (C) in nude mouse CRC models subcutaneously injected with HCT116 cells with or without xCT inhibition. D IHC staining showed the changes in the expression of Ki67, N-cadherin, E-cadherin, CD133 and P-AKT in CRC tissues after xCT knockdown. E The process to establish a CRC lung metastasis mouse model. F qRT-PCR and western blotting assays confirmed the knockdown efficiency with xCT shRNA administration in CT26 cells. Macroscopic changes in the lungs (G) and pathological changes in the lung tissues (H) of mice after caudal vein injection of CT26 cells with or without xCT inhibition. I xCT knockdown significantly inhibited the metastatic capability of CRC. *P < 0.05, **P < 0.01, ***P < 0.001.