Table 2.
Odds ratio and 95% CI of clinical outcomes for serum LDH before thrombolysis.
| LDH before thrombolysis, U/L (n = 527) | P value for trend | Each SD increase of Log-LDH | ||||
|---|---|---|---|---|---|---|
| Q1 (<163) | Q2 (163–184) | Q3 (185–212) | Q4 (>212) | |||
| Primary outcome: death or major disability (mRS score of 3–6) | ||||||
| No. of cases, n (%) | 21 (16.0%) | 25 (18.9%) | 22 (16.7%) | 59 (44.7%) | 127 (24.1%) | |
| Model 1 | Ref | 1.123 (0.568, 2.217) | 1.229 (0.614, 2.46) | 4.704 (2.45, 9.033) | <0.001 | 2.145 (1.651, 2.786) |
| Model 2 | Ref | 1.497 (0.671, 3.338) | 1.202 (0.506, 2.854) | 3.753 (1.645, 8.565) | 0.006 | 1.816 (1.329, 2.481) |
| Secondary outcomes | ||||||
| ENI | ||||||
| No. of cases, n (%) | 94 (71.7%) | 81 (61.4%) | 69 (52.3%) | 43 (32.6%) | 287 (54.5%) | |
| Model 1 | Ref | 0.946 (0.501, 1.787) | 0.590 (0.323, 1.078) | 0.218 (0.119, 0.399) | <0.001 | 0.496 (0.389, 0.633) |
| Model 2 | Ref | 0.888 (0.466, 1.691) | 0.576 (0.312, 1.062) | 0.261 (0.14, 0.489) | <0.001 | 0.540 (0.419, 0.697) |
| END | ||||||
| No. of cases, n (%) | 3 (2.5%) | 7 (5.3%) | 7 (5.3%) | 54 (41.9%) | 68 (13.0%) | |
| Model 1 | Ref | 1.754 (0.147, 20.927) | 2.308 (0.19, 27.974) | 16.605 (1.964, 140.368) | 0.001 | 2.970 (1.896, 4.653) |
| Model 2 | Ref | 2.011 (0.163, 24.785) | 1.944 (0.153, 24.641) | 8.699 (0.975, 77.574) | 0.062 | 2.258 (1.362, 3.743) |
| moderate-severe CE | ||||||
| No. of cases, n (%) | 5 (3.8%) | 7 (5.3%) | 13 (9.8%) | 28 (21.2%) | 53 (10.1%) | |
| Model 1 | Ref | 1.499 (0.435, 5.161) | 3.673 (1.184, 11.395) | 7.332 (2.493, 21.560) | <0.001 | 2.440 (1.690, 3.524) |
| Model 2 | Ref | 2.158 (0.561, 8.291) | 3.834 (1.079, 13.619) | 5.567 (1.650, 18.786) | 0.038 | 2.106 (1.408, 3.150) |
| sICH | ||||||
| No. of cases, n (%) | 7 (5.3%) | 2 (1.5%) | 9 (6.8%) | 10 (7.5%) | 28 (5.3%) | |
| Model 1 | Ref | 0.228 (0.043, 1.204) | 0.804 (0.382, 3.456) | 0.861 (0.276, 2.690) | 0.266 | 0.999 (0.828, 1.205) |
| Model 2 | Ref | 0.278 (0.053, 1.464) | 1.008 (0.318, 3.197) | 0.482 (0.141, 1.649) | 0.267 | 0.750 (0.473, 1.189) |
Model 1, adjusting for age, sex, admission blood glucose, time from onset to treatment, baseline systolic blood pressure, current smoking, alcohol consumption, history of stroke, hypertension, diabetes mellitus, dyslipidemia, coronary heart disease, and atrial fibrillation. Model 2, further adjusting for baseline National Institutes of Health Stroke Scale score based on adjusting for factors in model 1. ENI, early neurological improvement; CE, cerebral edema; sICH, symptomatic intracranial hemorrhage.