Table 3.

Reclassification and discrimination Statistics for clinical outcomes by serum LDH before thrombolysis.

Clinical outcomes		Continuous NRI, %		IDI, %
	Model	Estimate (95% CI)	P value	Estimate (95% CI)	P value
Primary outcome
Death or major disability (mRS score of 3–6)	Conventional model	Reference		Reference
	Conventional model + LDH quartile	0.4286 (0.2263, 0.611)	<0.001	0.0468 (0.0276, 0.066)	<0.001
	Conventional model	Reference		Reference
	Conventional model + log-transformed LDH	0.4114 (0.2133, 0.6095)	<0.001	0.0308 (0.0091, 0.0526)	0.005
Secondary outcomes
END	Conventional model	Reference		Reference
	Conventional model + LDH quartile	0.754 (0.3754, 1.1326)	<0.001	0.0337 (0.0135, 0.0538)	<0.001
	Conventional model	Reference		Reference
	Conventional model + log-transformed LDH	0.6445 (0.2017, 1.0872)	0.004	0.0564 (0.004, 0.1129)	0.04
ENI	Conventional model	Reference		Reference
	Conventional model + LDH quartile	0.6942 (0.4436, 0.9447)	<0.001	0.0877 (0.0576, 0.1177)	<0.001
	Conventional model	Reference		Reference
	Conventional model + log-transformed LDH	0.4138 (0.2232, 0.6043)	<0.001	0.0538 (0.0306, 0.6043)	<0.001
Moderate-severe CE	Conventional model	Reference		Reference
	Conventional model + LDH quartile	0.4512 (0.2607, 0.6418)	<0.001	0.0852 (0.0586, 0.1119)	<0.001
	Conventional model	Reference		Reference
	Conventional model + log-transformed LDH	0.6296 (0.3498, 0.9093)	<0.001	0.0353 (0.0086, 0.0619)	0.009

Conventional model was model 2 in Table 2, including age, sex, admission blood glucose, time from onset to hospitalization, baseline systolic blood pressure, current smoking, alcohol consumption, history of stroke, hypertension, diabetes mellitus, dyslipidemia, coronary heart disease, atrial fibrillation, and National Institutes of Health Stroke Scale score at baseline. IDI, indicates integrated discrimination index; and NRI, net reclassification improvement.