Table 4.
Subgroup analysis of the association between LDH before thrombolysis and primary outcome (death or major disability).
| Subgroup | Primary outcome: death or major disability (mRS score of 3–6) | |
|---|---|---|
| OR (95%CI) | P of interaction | |
| Age, y | ||
| <60 | 2.424 (1.212, 4.849) | 0.542 |
| 60–69 | 1.81 (1.294, 2.531) | |
| ≥70 | 1.595 (0.876, 2.902) | |
| Sex | ||
| men | 2.064 (1.381, 3.084) | 0.099 |
| women | 1.778 (0.695, 4.552) | |
| OTT, h | ||
| ≤ 3 | 2.341 (1.33, 4.121) | 0.434 |
| 3–4.5 | 1.65 (0.936, 2.907) | |
| > 4.5 | 1.518 (0.515, 4.477) | |
| SBP, mmHg | ||
| <160 | 1.767 (1.204, 2.594) | 0.875 |
| ≥160 | 3.859 (0.969, 15.358) | |
| Admission NIHSS score | ||
| <4 | 1.958 (1.117, 3.434) | 0.103 |
| ≥4 | 1.84 (1.269, 2.667) | |
| Admission blood glucose | ||
| <7.0 | 1.677 (0.931, 3.02) | 0.236 |
| <7.0 | 2.118 (1.393, 3.221) | |
| Hypertension | ||
| NO | 1.940 (1.001, 3.759) | 0.779 |
| YES | 1.777 (1.134, 2.784) | |
| Diabetes mellitus | ||
| NO | 2.03 (1.36, 3.029) | 0.2 |
| YES | 1.791 (0.778, 4.124) | |
| Dyslipidemia | ||
| NO | 1.391 (0.885, 2.187) | 0.057 |
| YES | 3.353 (1.433, 7.843) | |
| Previous ischemic stroke | ||
| NO | 1.779 (1.261, 2.51) | 0.788 |
| YES | 8.038 (0.181, 356.805) | |
| Previous intracerebral hemorrhage | ||
| NO | 1.897 (1.336, 2.643) | 0.36 |
| YES | 1.197 (0.003, 11.364) | |
| Coronary heart disease | ||
| NO | 1.843 (1.288, 2.637) | 0.845 |
| YES | 2.93 (0.43, 18.144) | |
| Atrial fibrillation | ||
| NO | 1.996 (1.275, 1.481) | 0.171 |
| YES | 1.983 (0.736, 5.347) | |
| Current cigarette smoking | ||
| NO | 1.714 (1.131, 2.597) | 0.419 |
| YES | 2.708 (1.287, 5.696) | |
| Current alcohol drinking | ||
| NO | 1.75 (1.206, 2.539) | 0.859 |
| YES | 2.045 (0.858, 4.873) | |
| Stroke subtype | ||
| Atherothrombotic | 1.973 (0.735, 5.295) | 0.651 |
| Cardioembolic | 2.014 (0.713, 6.221) | |
| Lacunar | 1.987 (1.008, 3.917) | |
| Lesion location | ||
| Anterior circulation | 1.917 (1.229, 2.991) | 0.118 |
| Posterior circulation | 1.045 (0.492, 2.22) | |
Interactions between serum LDH and interesting factors on the primary outcome were tested by the likelihood ratio test with adjustment for the same variables as model 2 in Table 2 unless the variable was used as a subgroup variable. NIHSS indicates National Institutes of Health Stroke Scale; and OR, odds ratio.