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. 2022 Apr 6;9:840647. doi: 10.3389/fcvm.2022.840647

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Copyright © 2022 Halawa, Latif, Tseng, Ibrahim, Chester, Moustafa, Aguib and Yacoub.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional classification of genes associated with differentially methylated promoters (q-value < 0.05 & meth.diff >|10|) between aortic and mitral tissue according to (A) Pathways, (B) Molecular Functions, (C) Biological Processes, (D) Protein Classes and (E) Cellular Components (selected results, the remaining can be found in Supplementary Figure 5– analysis performed using PANTHER). In the stacked bar graphs, TA (green) labels genes with promoters that show increased methylation in the aortic compared to the mitral valves and TM (red) shows genes whose promoters exhibit increased methylation in the mitral compared to the aortic valves.