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. 2022 Apr 6;9:797135. doi: 10.3389/fmed.2022.797135

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Copyright © 2022 Song, Lai, Lu, Tong and Ran.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptomic analysis of THP-1 macrophages exposed to IL-26. (A) Principal component analysis of protein-coding genes. (B) Volcano plots showing protein-coding genes from untreated and IL-26-treated macrophages, red and blue indicate the significantly upregulated and downregulated genes, respectively. (C) Heatmap of differentially expressed protein-coding genes between untreated and IL-26-treated macrophages. (D) GO enrichment analysis (biological process) of up-regulated genes. (E) Top 20 from the KEGG enrichment analysis of up-regulated genes ranked by q-value. (F) GSEA analysis of all protein-coding genes in IL-26-treated macrophages.