Table 1.

PI3K/AKT/mTOR pathway genomic alterations for HGSOC in TCGA*, ICGC OV-AU^§ and BriTROC-1 cohorts

Gene	Alteration	Frequency of alteration %
		TCGA*	ICGC(OV-AU)§	BriTROC-1
AKT1	Amplification	2.9-5.2	2.2
	Deletion	0-0.2
	Mutation	0.3	3.3
AKT2	Amplification	5.8-8	9.8	11.4
	Deletion	0.3-1
	Mutation		3.3
AKT3	Amplification	4.1-9.5	4.3
	Deletion	0.2-0.4
	Mutation	1	7.6
PIK3CA	Amplification	18-29	22.8
	Mutation	1	2.2	4.6
PIK3CB	Amplification	3.9-11.4	13.0
	Mutation	0.3	1.1	2.3
PIK3R1	Amplification	0-0.2
	Deletion	2-3.5
	Mutation	2	2.2
PTEN	Amplification	0.7-1.2
	Deletion	4.5-6.1	2.2
	Mutation	1	6.5
RICTOR	Amplification	3.5-7.1	3.3	9.1
	Mutation		1.1

Mutation types include missense mutations, truncating mutations or fusion. *TCGA studies accessed via cBioPortal; data presented involve the range of 3 studies. ^§ICGC OV-AU cohort accessed via https://icgc.org/4cV. BriTROC-1 data accessed via^[63].