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. 2021 Mar 19;4(1):143–162. doi: 10.20517/cdr.2020.54

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© The Author(s) 2021.

© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Metabolic mechanisms of resistance to endocrine therapies: the androgen receptor (AR) and lipid metabolism crosstalk. A: overview of lipid metabolism changes mediating resistance to androgen deprivation therapy (ADT) and androgen receptor signaling inhibitors (ARSI); B: schematic representation of AR signaling and lipid metabolism crosstalk. Drug targeting fatty acid (FA) synthesis and FA oxidation (FAO) are indicated as potential non-canonical approaches to inhibit AR signaling in mCRPC. CPT1: carnitine palmitoyltransferase 1; FASN: fatty acid synthase; SREBPs: sterol regulatory-element binding proteins