. 2019 Dec 19;2(4):1127–1135. doi: 10.20517/cdr.2019.76

Table 1.

The significance of OCSCs to recurrence and chemoresistance

Marker	Significance	Cell lines/Specimens	Ref.
CD24	Cytoplasmic localisation of CD24⁺ is indicative of poor prognosis and predictive of recurrence	Human ovarian serous tumours	[16]
CD24	Increased metastasis and chemoresistance in CD24⁺ cells that have developed cisplatin-resistance	CAOV-3 cell line	[17]
CD44	CD44⁺/CD24^- expression in cells is predictive of recurrence	Human OC cells isolated from ascites	[18]
CD117	CD117⁺/c-Kit⁺ expression in cells is characteristic of chemoresistance	Human advanced serous ovarian carcinoma	[19]
CD117	Therapy with paclitaxel increases CD177 expression in vivo	Primary tumour xenografts	[20]
CD133	Higher cisplatin IC₅₀ in CD133⁺ cells characteristic of chemoresistance	42 established OC cell lines	[21]
ALDH	ALDH1A1 expression in OCSCs correlates with poor survival and chemoresistance	Human high-grade OC tumours	[13]

OC: ovarian cancer; OCSCs: ovarian cancer stem cells