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. 2019 Dec 19;2(4):1069–1085. doi: 10.20517/cdr.2019.87

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© The Author(s) 2019.

© The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Timeline of rapamycin and rapalogs from discovery to clinic. Rapalogs include temsirolimus, everolimus and ridaforolimus. RCC: renal cell carcinoma; SEGA: subependymal giant cell astrocytoma; BC: breast cancer; PNET: pancreatic neuroendocrine tumours; FDA: Food and Drug Administration (United States of America)