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. 2022 Jan 29;298(4):101653. doi: 10.1016/j.jbc.2022.101653

Figure 2.

Figure 2

CRL4 ligase complex models with different DDB1 conformations.A, different DDB1 conformations. B, CRL4A ligase complex conformation with reasonable distance (≤4 Å distance) between CRBN and E2 enzyme. C, CRL4A ligase complex conformation with a big gap (>4 Å distance) between CRBN and E2 enzyme. D, CRL4A ligase complex conformation with clashing between CRBN and E2 enzyme. CRBN is shown in forest; DDB1 is shown in pale green; Cul4A is shown in light blue; Rbx1 is shown in pink; NEDD8 is shown in wheat; E2 (UBE2D1) is shown in pale yellow; and ubiquitin is shown in sky blue.