. 2022 Jan 29;298(4):101653. doi: 10.1016/j.jbc.2022.101653

Table 1.

Different CDK family members with multikinase degrader

Target protein	Dmax₅₀ (nM)^a	# Surface lysine	# Ternary complex models	% Productive	Ubiquitination EC₅₀ (nM)
CDK5	62	22	4157	57	Not tested
CDK7	233	14	14,452	24	428
CDK8	>500	33	29,920	14	888
CDK9	58	26	9802	33	297
CDK12	7	31	4359	77	16
CDK13	7	29	12,018	62	7

Dmax₅₀ values are from Riching et al. (48).