Fig. 2.

The phenotype of Ostα^-/- and Ostβ^-/- mice compared with wild-type littermates at 4 and 8 weeks of age in females and males.

(A) Plasma ALT, ALP and AST levels of 8–12-week-old male mice. (B) Body weight, (C) length of small intestine and (D) weight of small intestine of 4- or 8-week-old male and female mice. Data are expressed as the mean ±SD with individual points shown in dots (n = 7–13 mice per group). Statistical analysis was done using a one-way ANOVA test and Dunnett’s test to compare with wild-type littermates. ∗Indicates p values of <0.05. ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BW, body weight; Ostα, organic solute transporter alpha; Ostβ, organic solute transporter beta; wk, week.