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. 2022 Mar 5;4(5):100463. doi: 10.1016/j.jhepr.2022.100463

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 4 — Altered expression of differentiation markers in Ostα^-/- and Ostβ^-/- mice.

Ileal mRNA expression of 4- and 8-week-old Ostα^-/-, Ostβ^-/- and wild-type males of (A) Cdx2, (B) Sis (C) Fgf15 and (D) Asbt. Data are normalized using the geometric mean of CyclophillinB and Rpl4. Data are shown as the mean ±SD with individual points shown in dots (n = 4-7). Statistical analysis was performed using a one-way ANOVA test, and Dunnett’s test to compare with wild-type littermates. ∗Indicates p values of <0.05. Asbt, apical sodium-dependent bile acid transporter; Cdx2, caudal type homeobox 2; Fgf15, fibroblast growth factor 15; Ostα, organic solute transporter alpha; Ostβ, organic solute transporter beta; Sis, sucrose-isomaltase; wk, week; WT, wild-type.