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. 2021 Jun 19;4(2):264–297. doi: 10.20517/cdr.2020.81

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© The Author(s) 2021.

© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Schematic representation of the SLNs structure, representing the solid lipid matrix, surfactant, and co-surfactant^[83] (A); Classification of three types of classical SLNs including drug-enriched shell, drug-enriched core, and solid solution^[85] (B); Images of spheroids formation in different period of time with respective size (μm). MCF-7/ADR (a), NCI/ADR (b). Images are representative of triplicate samples^[93] (C); Development of fucose decorated methotrexate loaded SLNs (D). The proposed mechanism of action is methotrexate via ligand-receptor mediated endocytosis and internalization^[96]