Supplementary Figure 1.

FGF19 overexpression modulate bile acid (BA) pool composition and hydrophobicity in the bile. Bile acids measurements were performed on mouse bile by high performance liquid chromatography-tandem mass spectrometry. The data presented here correspond to a detailed presentation of data presented in Figure 1E right panel A. Relative abundance of primary BA as a percentage of total BA concentrations. B. Relative abundance of secondary BA as a percentage of total BA concentrations. C. Bile hydrophobicity index in control and FGF19 mice. All unpaired t test. Mean +/- SD. N.s: not significant. n.d: not detectable. Abbreviations: CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; MCA, muricholic acid; HDCA, hyodeoxycholic acid. D. Bile acids concentration in bile of control and FGF19 overexpressing mice. Mean, SD and Mann-Whitney test statistical significance are shown.