Table 2.
Glucose, cortisol, and growth hormone responses to the ITT.
| Standard dose 0.15 U/kg | Low dose 0.10 U/kg | |
|---|---|---|
| Glucose (mmol/L) | n = 113 | n = 61 |
| Nadir mean ± SD (range) | 1.07 ± 0.36 (0.30–2.20) | 1.16 ± 0.40 (0.40–2.10) |
| Growth hormone (µg/L) | n = 112 | n = 60 |
| Adequate response (>3.0) n (%) | 82 (73.2%) | 45 (75.0%) |
| Mean ± SD (range) | 13.3 ± 8.8 (3.1–44.9) | 16.5 ± 12.4 (3.1–55.6) |
| Time point when >3 | n (% of 82) | n (% of 45) |
| 0 min. | 6 (7%) | 5 (11%) |
| 30 min. | 25 (30%) | 14 (31%) |
| 45 min. | 63 (77%) | 33 (73%) |
| 60 min. | 81 (99%) | 43 (96%) |
| 90 min. | 82 (100%) | 45 (100%) |
| 120 min. | — | — |
| Inadequate response (≤3.0) n (%) | 30 (26.8%) | 15 (25.0%) |
| Mean ± SD (range) | 1.1 ± 0.8 (0.1–2.8) | 1.3 ± 1.0 (0.03–2.9) |
|
| ||
| Cortisol (nmol/L) | n = 106 | n = 60 |
| Adequate response (>450) n (%) | 77 (72.6%) | 32 (53.3%)∗ |
| Mean ± SD (range) | 560 ± 66 (456–799) | 519 ± 61∗∗ (452–731) |
| Time point when >450 | n (% of 77) | n (% of 32) |
| 0 min. | 3 (4%) | 1 (3%) |
| 30 min. | 5 (6%) | 2 (6%) |
| 45 min. | 36 (47%) | 7 (22%)∗ |
| 60 min. | 71 (92%) | 26 (81%) |
| 90 min. | 77 (100%) | 32 (100%) |
| 120 min. | — | — |
| Borderline response (400–450) n (%) | 10 (9.4%) | 7 (11.7%) |
| Mean ± SD (range) | 417 ± 27 (403–439) | 424 ± 15 (409–440) |
| Inadequate response (<400) n (%) | 19 (17.9%) | 21 (35.0%)∗ |
| Mean ± SD (range) | 233 ± 133 (19–393) | 284 ± 121 (7–397) |
∗ p < 0.05 vs. standard, ∗∗∗p=0.001 vs. standard.