TABLE 3.
Experimentally determined values of Michaelis-Menten constant (K m) for urate of human urate transporters expressed in the kidney.
| Renal urate transporters | Localization a | K m for urate (μM) | References |
|---|---|---|---|
| SLC22A family proteins | |||
| URAT1/SLC22A12 | PT, AM | 371 | Enomoto et al. (2002) |
| OAT10/SLC22A13 | PT, AM | 558 | This paper |
| OAT1/SLC22A6 | PT, BLM | 943 | Ichida et al. (2003) |
| OAT2/SLC22A7 | PT, AM or BLM | 1,168 | Sato et al. (2010) |
| OAT3/SLC22A8 | PT, BLM | 2,888 | Kimura et al. (2000) |
| OAT4/SLC22A11 | PT, AM | 3,780 | Kimura et al. (2001) |
| Others | |||
| GLUT9/SLC2A9 | PT, AM and BML | 890; 981 | Vitart et al. (2008); Caulfield et al. (2008) |
| ABCG2 | PT, AM | 8,240 | Matsuo et al. (2009) |
a
Information of the localization of each protein in the kidney are from a previous study (Burckhardt, 2012). URAT, urate transporter; OAT, organic anion transporter; GLUT, glucose transporter; ABCG2, ATP-binding cassette transporter G2; PT, proximal tubule; AM, apical membrane; BLM, basolateral membrane.