Table 2.
Germline transmission of six founder crosses for the oca2 loss of function mutations.
| group | founder cross | #F1s tested | positive individuals | germline transmission (%) |
|---|---|---|---|---|
| oca2 mosaic male × WT females: germline transmission quantified by PCR genotyping | ||||
| #1 oca2 exon 1 | oca2♂1 × wt♀ | 9 | 7 | 78 |
| #2 oca2 exon 1 & 3 | oca2♂2 × wt♀ | 9 | 0 | 0 |
| #3 oca2 exon 1 & 3 | oca2♂3 × wt♀ | 9 | 7 | 78 |
| #4 oca2 exon 1 & 3 | oca2♂4 × wt♀ | 9 | 3 | 33 |
| average transmission | 47 | |||
| oca2 mosaic × oca2 mosaic: germline transmission quantified by presence of amelanistic individuals | ||||
| #5 oca2 exon 1 | oca2♂5 × oca2♀1 | 10 | 10 | 100 |
| #6 oca2 exon 1 | oca2♂5 × oca2♀2 | 10 | 2 | 20 |
| average transmission | 60 | |||