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. 2022 Apr 20;12:6485. doi: 10.1038/s41598-022-10481-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Heatmap representing the significant Spearman's correlations (adjusted for age, gender, BMI, and T2D) between the clinical parameters (column-wise) and the top significantly different metabolites identified in all sample matrices combined (row-wise) using delta change from baseline to post intervention. The color of the cells indicates the strength of the relationship (r_s). The cells marked with asterisks (*) demonstrate significant correlations (p < 0.05). Green sidebars indicate the control group, and red sidebars represent the exercise intervention group. Waist cm waist circumference, IHL intrahepatic lipid content, ALT alanine aminotransferase, AST aspartate transaminase, gGT gamma-glutamyl transferase, VO₂max the maximum rate of oxygen consumption (cardiorespiratory fitness), maxW maximum workload achieved, TC total cholesterol, HDL high-density lipoprotein cholesterol.