TABLE 3.

Predicted free energies (kcal/mol) for binding of foretinib and 17l to c-Met kinase.

Energy terms (kcal/mol)	Foretinib	17l
VDW energy a	−56.890 ± 1.764	−58.850 ± 0.765
EE energy b	−10.453 ± 1.081	−9.239 ± 0.510
Polar energy c	41.902 ± 2.074	39.615 ± 0.624
Apolar energy d	−6.008 ± 0.132	−5.470 ± 0.058
Delta total e	−31.448 ± 1.414	−33.944 ± 0.961

^{Note. a}Van der Waal energy.

^bElectrostattic energy.

^cPolar solvation energy.

^dSASA, energy.

^eBinding energy.