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. Author manuscript; available in PMC: 2022 Apr 20.
Published in final edited form as: Reprod Sci. 2008 Nov;15(9):878–894. doi: 10.1177/1933719108324171

Figure 1.

Figure 1.

2-Methoxyestradiol (2ME) and 2-hydroxyestradiol, but not other estrogen metabolites, increase cytotoxicity in the ovarian cancer cell line A2780. Cell cytotoxicity was measured by the MTS assay, and the data represented as a percentage in respect to control (ethanol, C) in the presence or absence of 4-hydroxyestradiol (40H), 4-methoxyestradiol (4ME), 2-methoxyestradiol (2ME), 2-hydroxyestradiol (20H), and 17-beta estradiol (E2). All concentrations were 2 μM in ethanol vehicle. Standard deviation of the mean is shown from a minimum of 3 experiments performed, each consisting of 5 replicates. Mann-Whitney test statistical significance (★) was set at P < .05 with respect to control (vehicle).