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. Author manuscript; available in PMC: 2022 Apr 20.
Published in final edited form as: Reprod Sci. 2008 Nov;15(9):878–894. doi: 10.1177/1933719108324171

Figure 12.

Figure 12.

2-Methoxyestradiol (2ME) upregulates TRAIL-R2 in ovarian cancer cell line A2780. A, RT-PCR of TRAIL-R1, TRAIL-R2, TRAIL-R3, and TRAIL-R4 mRNA with 2ME 5 μM for 9 hours. B, Densitometric analysis of the TRAIL-R2 and TRAIL R4 RT-PCR. Statistical significance (★) in respect to vehicle treated control for each cell type was set at P < .05 using the Mann-Whitney test. C, Immunocytochemistry demonstrating that the increases in mRNA levels are mirrored at the protein level after 24 hours of 2ME treatment.