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. Author manuscript; available in PMC: 2022 Apr 20.
Published in final edited form as: Reprod Sci. 2008 Nov;15(9):878–894. doi: 10.1177/1933719108324171

Figure 4.

Figure 4.

2-Methoxyestradiol (2ME) mediates apoptosis via an estrogen receptor independent pathway. Cell cytotoxicity was measured by the MTS assay. The competitive estrogen receptor antagonist ICI 182780 (ICI, 0.5, 1, and 2 μM) was added for 30 minutes prior to 2-methoxyestradiol (2ME, 5 μM) addition for 48 hours. Data represented as a percentage in respect to control. Standard deviation of the mean is shown from a minimum of 3 experiments performed, each consisting of 5 replicates. Mann-Whitney test set statistical significance at ★ = P < .05 with respect to control.