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. Author manuscript; available in PMC: 2022 Apr 20.
Published in final edited form as: Reprod Sci. 2008 Nov;15(9):878–894. doi: 10.1177/1933719108324171

Figure 9.

Figure 9.

2-Methoxyestradiol (2ME) enhances TRAIL-mediated apoptosis in the ovarian cancer cell lines A2780 and UCI 101. Cytotoxicity was measured by the MTS assay in A2780 cells and UCI 101 cell line (Panel A). Cells were treated with ethanol vehicle (Control), TRAIL 200 ng/mL for 18 hours, 2ME for 48 hours or 2ME for 48 hours with TRAIL addition occurring 18 hours before the end of the experiment (2ME + TRAIL). Using the Mann-Whitney test, statistical significance in change in cytotoxicity in respect to vehicle treated control (★) and in respect to 2ME administration (#) for each drug was set at P < .05. Panel B, western blot analysis of PARP in the presence of above-stated treatments, b-actin is used as a loading control.