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. 2022 Apr 6;13:859513. doi: 10.3389/fgene.2022.859513

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Copyright © 2022 Pang, Pan, Lin, Li, Yuan, Han, Ji, Li, Wang, Chu, Wu, Fan, Du and Ji.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The motif analysis of eccDNA junctions. The nucleotide composition from 15 bp upstream to 15 bp downstream of the start (Junction 1) and end position (Junction 2) of the eccDNA junction in acute gout (A) and healthy control (B). The frequency of base distribution at each position is plotted as a stacked histogram. The size of four bases at each position in the figure reflects their frequency. The 3-bp motifs flanking the start and end site in acute gout (C) and healthy control (D). Data were ranked by motif frequencies. I, II, III, IV refers to 3-bp upstream of start site, 3-bp downstream of start site, 3-bp upstream of end site, and 3-bp downstream of end site, respectively.