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. 2022 Apr 6;9:828886. doi: 10.3389/fmolb.2022.828886

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Copyright © 2022 Li, Su, Xiao, Wu, Du, Guo, Kong, Yao and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association between CD86 and TIICs. (A) CD86 expression in normal bone and osteosarcoma tissues (GSE16088). (B) Correlation between CD86 expression and CTLA4 or CD28 expression in validation cohort (TARGET). (C) Associations between CD86 expression and infiltration of naïve B-cells, M2 macrophages, and regulatory T-cells in the validation cohort (TARGET). (D) Correlation between CTLA4 or CD28 expression and infiltration of CD8 T-cells, Tregs, and memory CD4 T-cells in the validation cohort (TARGET).