TABLE 3.
Metoprolol maintenance doses and weight-adjusted doses of NMs and IMs.
| NMs | IMs | P | ||||
|---|---|---|---|---|---|---|
| N | Value a | N | Value a | |||
| Initial dose (mg/day) | ||||||
| dose≤12.5 | Maintenance doses (mg/day) | 50 | 12.5 (12.5–25) | 39 | 12.5 (12.5–25) | 0.922 |
| Weight-adjusted doses (mg/day/kg) | 0.35 ± 0.32 | 0.30 ± 0.18 | 0.330 | |||
| 18.75–25 | Maintenance doses (mg/day) b | 182 | 25 (25–50) | 93 | 25 (25–25) | <0.001 |
| Weight-adjusted doses (mg/day/kg) | 0.44 ± 0.19 | 0.31 ± 0.11 | <0.001 | |||
| 31.25–50 | Maintenance doses (mg/day) b | 330 | 50 (25–50) | 188 | 50 (25–50) | 0.009 |
| Weight-adjusted doses (mg/day/kg) | 0.57 ± 0.21 | 0.48 ± 0.24 | <0.001 | |||
| >50 | Maintenance doses (mg/day) b | 35 | 50 (25–75) | 18 | 50 (25–50) | 0.046 |
| Weight-adjusted doses (mg/day/kg) | 0.73 ± 0.46 | 0.52 ± 0.22 | 0.030 | |||
| Total | Maintenance doses (mg/day) | 597 | 50 (25–50) | 338 | 25 (25–50) | <0.001 |
| Weight-adjusted doses (mg/day/kg) | 0.52 ± 0.25 | 0.42 ± 0.22 | <0.001 | |||
NMs, normal metabolizers; IMs, intermediate metabolizers.
a
Presented as mean ± standard deviation or median (interquartile range) as appropriate.
b
NMs and IMs have the same median values but the different distribution shape of maintenance doses. In Mann–Whitney U test, NMs have higher mean rank than IMs, leading to the statistical significance between two groups.