TABLE 2.

Summary of nervous system disease effects of Re.

Inducer	Experimental Model	Outcome and Proposed Mechanism	Reference(s)
Surgery	SD rats, Schwann cell	PCNA↑, GAP-43↑, S100↑, p-ERK1/2↓, p-JNK1/2↓	Wang et al. (2015)
MCAO model	SD rats	SOD↑, GSH-Px↑, Average microviscosity↓, MDA↓	Zhou et al. (2006)
MCAO model	SD rats	H+-ATPase activity↑, MDA↓	Chen et al. (2008)
TMT	IL-6(−/+) C57BL/6 mice	c-FOS-IR↑, IL-6↑, p-Akt↑, IFN-γ↓, TNF-α↓, IL-1β↓, MDA↓, ROS↓	Tu et al. (2017)
PCP	C57BL/6mice, GPx-1 knockout mice	GPx-1↑, PHOX activity↑	Tran et al. (2017)
RIS	SD rats	BDNF↑, Behavioral deficits↓, TH↓	Lee I et al. (2012)
CRS	C57BL/6J mice	BDNF↑, Nrf2↑, HO-1↑, SYP↑, PSD95↑, NLRP3↓, ASC↓, Caspase-1↓	Wang et al. (2021)
MPTP	C57BL mice	Bcl-2↑, iNOS↑, caspase-3↑, TH-positive neurons↑, Bax↓	Xu et al. (2005)
MA	PKCδ(+/−) C57BL/6 mice	SOD↑, catalase↑, GPx↑, DA↑, dopaminergic degeneration↓, PKCδ↓	Shin et al. (2014)
MA	DYN KO mice	κ-opioid receptor↓, P-mediated NK1 receptor↓	Dang et al. (2018)
CCl4	Primary dopaminergic cell	Neurites of TH cells↑, Neuritic lengths↓	Zhang et al. (2016)
MA	SH-SY5Y cell	Cell viability↑, GPx↑, GSH↑, TH activity↑, PKCδ↓	Nam et al. (2015)
	Dopaminergic neuronal cell, Hsp60 KD cell, PINK1 null dopaminergic cell lines	Hsp90↑, LRPPRC↑, Hsp60↑	Kim et al. (2012)
Rotenone	SH-SY5Y cells	SOD↑, GSH/GSSG↑, aconitase↑, Nrf2↑, ROS↓, Caspase-3↓, Bax/Bcl2↓, Cytochrome c↓	Gonzalez-Burgos et al. (2017)
6-OHDA	SH-SY5Y cells	Cell viability↑, GPX4↑, p-Akt↑, p-ERK↑, LDH↓, ROS↓, lipid peroxidation↓	Lee et al. (2020)
Scopolamine	CR mice, Wistar rats	Escape latency↓	Wang et al. (2010)
	Tg2576 mice	Aβ-40↓, Aβ-42↓	Zhou et al. (2020)
	CHO 2B7 cells, Aβ-lesioned mice	Aβ-40↓, Aβ-42↓	Chen et al. (2006)
Aβ-25-35 peptide	Kunming mice	phenylalanine↓, tryptophan↑, hexadecasphinganine↑, phytosphingosine↑, LPCs↑	Li et al. (2018)
Surgery and microdialysis	SD rats	DA↑, Ach↑, mPFC	Shi et al. (2013)
	N2a/APP695 cells	PPARγ↑, Aβ1-40↓, Aβ1-42↓, β-amyloid, BACE1↓	Cao et al. (2016)
Aβ+serum free	PC12 cells	LDH↓, cell toxicity↓	Ji et al. (2006)
Aβ	SH-SY5Y cells	GSH↑, SOD↑, GPx↑, ROS↓, Bcl2/Bax↓, Nrf2↓, Caspase-3/9↓, Cytochrome c↓, p-ASK-1↓, p-JNK↓, HO-1↓	Liu et al. (2019)
	Neuro-2a cells	MAP-2↑, p75↑, p21↑, TrkA↑, ChAT/VAChT↑	Kim M et al. (2014)