TABLE 5.

Summary anti-cancer effects of Re.

Inducer	Experimental Model	Outcome and Proposed Mechanism	Reference(s)
CDDP	LLC-PK1 cells, Wistar rats	Cell viability↑, DPPH radical-scavenging activity↑, Caspase-3↑, Renal cortex tissue tubular damage↓	Lee W et al. (2012),
			Kim J et al. (2014)
CDDP	ICR mice	CAT↑, GSH↑, Bcl2/Bax↑, CRE↓, BUN↓, MDA↓, 4-HNE↓, CYP2E1↓, COX-2↓, iNOS	Wang et al. (2018c)
CTX	BALB/c mice	Erythropoietin↑, thrombopoietin↑, TPO↑, RBCs↑, hemoglobin↑, platelets S phase↑, Bcl-2↑, WBCs↓, thymus index↓, BMNC↓, spleen index↓, Bax↓, Caspase-3↓	Han et al. (2019)
	SW480 cells	Apoptosis↑, Cell proliferation↓	Xie et al. (2011)
	293T, MCF-7, A375, HepG2 cells	LDH release↑, Cell viability↓, ROS↓, Caspase-3↓	Yao et al. (2018)