TABLE 1.
Select genes that are significantly differentially expressed following transfection with phosphorothioate AOs. All with Log2FoldChange of ±0.7and p adj < 0.05.
| Gene function | Key gene transcripts downregulated | Key gene transcripts upregulated |
|---|---|---|
| Paraspeckle formation | NONO, HNRNPA1 | |
| Long non-coding RNAs | MALAT1 | |
| Housekeeping | ACTB, GAPDH, LMNA, TUBB | CCND1 |
| ALS/neurodegenerative disease linked genes | TARDBP, SOD1, SQSTM1, NEK1, HNRNPA1, VCP | |
| Regulation of autophagy | BECN1, MAP1LC3B2, LAMP2, ATG4A/B/C | |
| Mitochondrial genes | PINK1, OMA1, TOMM7, TOMM20, OPA1, PRDX3, NDUFS1 | |
| Chromatin regulators and remodelers | CHD3, CHD4 CHD6, BRD7, RSF1, PRMT2, ATM | CHD2, CHD5, CHD7 |
| SRSF splicing factor family | SRSF5, SRSF9, SRSF11 | SRSF7, SRSF12 |
| hnRNP splicing factor family | HNRNPA0/1/3, HNRNPC, HNRNPD, HNRNPH1/2, HNRNPK, HNRNPM, HNRNPU | |
| PRPF splicing family | PRPF6, PRPF8, PRPF19, PRPF31, PRPF38A, PRPF40 A/B | |
| HDAC family | HDAC1, HDAC2, HDAC5, HDAD6, HDAC7, HDAC8, HDAC10, HDAD11 | HDAC9 |
| Transcription factors | TP53, SP1, SUPT3H, SUPT4H1, SUPT5H, SUPT7L | MYC, E2F1 |
| Stress markers | NPM1, FBL, TIA1, G3BP1 | NOP2 |