FIGURE 3.

BCD normalizes estrous cycling and serum sex hormones. (A) Representative images of the estrous cycle phases. Briefly, diestrus is suggested with a significant proportion of leukocytes, proestrus by primarily nucleated epithelial cells, estrus by cornified epithelial cells, metestrus by leukocytes, nucleated epithelial cells, and cornified epithelial cells. BCD augments serum sex hormone levels in TWP-enhanced POI mice, and (B) AMH, (C) INHB, (D) FSH, (E) LH, (F) The ratio of FSH to LH and (G) E₂ serum concentration were evaluated using ELISA. Data is visualized in means ± SEM. (n = 8, *p < 0.05, **p < 0.01, compared with the Blank group; ^# p < 0.05, ^## p < 0.01, compared with the Model group; ★p < 0.05, ★★p < 0.01, compared with the BCD group).