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. 2022 Mar 28;23(5):353. doi: 10.3892/etm.2022.11280

Figure 4.

Figure 4

Effect of miR-223 agomir on thalamic pain. Baseline behavior tests were performed 1 day prior to miR-223 agomir or agomir-scramble microinjection into the VPL and VPM nuclei. Three days after administration of miR-223 agomir/agomir scramble, Coll IV or saline was microinjected into the VPL and VPM nuclei. Administration of miR-223 agomir significantly attenuated the increase in paw withdrawal frequency in response to (A) 0.07 g and (B) 0.4 g von Frey filaments and the significant decrease in paw withdrawal latency to (C) thermal and (D) cold stimuli on day 1, 3 and 5 following Coll IV microinjection on the contralateral side. (E-G) Administration of miR-223 agomir or agomir scramble did not affect behavioral changes on the ipsilateral side. n=8 mice/group. *P<0.05 vs. saline + agomir-scramble at the corresponding time points; #P<0.05 vs. Coll IV + agomir-scramble at the corresponding time points. miR, microRNA; VPL, ventral posterior lateral; VPM, ventral posterior medial; Coll IV, collagenase IV.