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. 2022 Mar 28;23(5):353. doi: 10.3892/etm.2022.11280

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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NLRP3 inflammasome inhibitor rescues miR-223 antagomir-induced thalamic pain in naïve mice. Tail vein injection of CY 09 (10 mg/kg) significantly attenuated the increase in paw withdrawal frequency in response to (A) 0.07 g and (B) 0.4 g von Frey filaments and the decrease in paw withdrawal latency to (C) thermal and (D) cold stimuli on day 3, 5 and 7 on the contralateral side. (E-G) Injection of CY 09 or vehicle did not cause behavioral changes on the ipsilateral side. n=8 mice/group. ^*P<0.05 vs. naïve group at the corresponding time points; ^#P<0.05 vs. naïve + miR-223 antagomir + vehicle group at the corresponding time points. NLRP3, NLR family pyrin domain containing 3; miR, microRNA.