Figure 1.

Time course of serologic evidence of acetaminophen-induced hepatic injury in wild type (WT) and AKBI mice. WT and AKBI (IkappaB beta [IκBβ] knock-in mice) unexposed mice were evaluated. A, Representative Western blot of nuclear factor kappa B inhibitory proteins IkappaB alpha (IκBα) and IκBβ, as well as CYP2E1, in hepatic lysates, with total protein shown as loading control. Densitometric analysis of B, IκBα and C, IκBβ in hepatic lysates. D, Fold change hepatic mRNA expression of Cyp2e1. E, Densitometric analysis of CYP2E1 in hepatic lysates. White columns represent WT mice and black columns represent AKBI mice (n = 4–8). Data are expressed as mean ± SEM; *p < .05 versus unexposed WT-controls.