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. 2021 Nov 2;185(2):158–169. doi: 10.1093/toxsci/kfab131

Figure 4.

Figure 4.

Hepatic redox response to acetaminophen (APAP) exposure (280 mg/kg, IP) in wild type (WT) and AKBI mice. WT and AKBI (IkappaB beta knock-in mice) were exposed to APAP (280 mg/kg, IP) for 0, 8, or 24 h. A, Total glutathione protein content. Fold change hepatic mRNA expression of B, Gclc, C, Gclm in unexposed mice. D, Glutathione peroxidase activity, expressed as fold change from WT control. E, Thioredoxin reductase (Trxrd) activity, expressed as fold change from WT control. Fold change hepatic mRNA expression of F, Nqo1, G, Gclc, H, Trxrd1. White columns represent WT mice and black columns represent AKBI mice (n = 4–20). Data are expressed as mean ± SEM; *p < .05 versus genotype-matched control and †p < .05 versus time-matched exposure.