Figure 6.

Hepatic nuclear factor kappa B (NFκB) transcriptional response to acetaminophen (APAP) exposure in wild type (WT) and AKBI mice. WT and AKBI (IkappaB beta knock-in mice) were exposed to APAP (280 mg/kg, IP) for 0, 8, or 24 h. Fold change hepatic mRNA expression of A, Nos2, B, Il1b, C, Tnf, D, Cxcl1, E, Ccl2, F, Ccl3, G, Icam1, and H, Il6. White columns represent WT mice and black columns represent AKBI mice (n = 5–21). Data are expressed as mean ± SEM; *p < .05 versus genotype-matched control and †p < .05 versus time-matched exposure.