Figure 5.

Schematic diagram of the effect of FTL on the cell cycle. FTL may have increased proliferative capacity of malignant mesothelioma by suppressing DNA checkpoint associated genes, p21 and p27, inducing activation of CDK2, which inactivated Rb by phosphorylation into pRb and activated E2F to promote the cell cycle. Orange arrows indicate the estimated status of each gene in malignant mesothelioma, blue arrows indicate the activation of the pathway and blue bars indicate suppression of the pathway. FTL, ferritin light chain; E2F, early 2 factor; RB, retinoblastoma protein; p-, phosphorylated.