Fig. 5.

Effect of Nintedanib and Imatinib in GIST‐882 mouse xenograft models in vivo. (A) Effects of nintedanib and Imatinib on the FGFR signalling pathways in GIST‐882 mouse xenograft models (control, n = 2, independent experiments; treated, n = 3, independent experiments). (B‐D) Effect of nintedanib and imatinib on GIST‐882 mouse xenograft models (n = 5, independent experiments). (E) Effects of nintedanib and imatinib on the FGFR signalling pathways in GIST‐882 mouse xenograft models after treated by 40 days (n = 3, independent experiments). Animals were treated orally once a day with a various of dose of the drugs. Data are shown as mean ± SEM, *P‐value < 0.05; **P‐value < 0.01; ***P‐value < 0.001 (one‐way ANOVA).