TABLE 3.

Associations of brain menaquinone‐4 (MK4) concentrations with brain pathology (n = 325)

	MT & MF cortex		AWS		CR
	β (SE)	P‐value	β (SE)	P‐value	β (SE)	P‐value
Dichotomous outcomes:
Braak ≥IV	−0.173 (0.083)	.038	−0.157 (0.071)	.027	−0.172 (0.085)	.044
CERAD neuritic plaque score	−0.133 (0.085)	.12	−0.141 (0.074)	.06	−0.156 (0.088)	.07
AD based on NIA Reagan	−0.109 (0.083)	.19	−0.112 (0.071)	.12	−0.120 (0.085)	.16
Presence of gross chronic infarcts	0.041 (0.074)	.58	0.0004 (0.065)	.99	−0.037 (0.077)	.63
Presence of chronic microinfarcts	0.046 (0.075)	.54	0.072 (0.066)	.27	0.014 (0.078)	.86
Presence of Lewy body disease a	−0.168 (0.084)	.045	−0.135 (0.074)	.07	−0.193 (0.090)	.032
Continuous outcomes:
Global AD pathology	−0.025 (0.013)	.05	−0.026 (0.011)	.020	−0.021 (0.013)	.11
Amyloid beta	−0.017 (0.040)	.67	−0.028 (0.035)	.42	−0.019 (0.041)	.65
Diffuse plaques	−0.021 (0.016)	.20	−0.017 (0.014)	.23	−0.020 (0.017)	.23
Neuritic plaques	−0.022 (0.018)	.21	−0.021 (0.015)	.17	−0.019 (0.018)	.30
PHF‐tau tangle density	−0.023 (0.015)	.12	−0.025 (0.013)	.05	−0.019 (0.015)	.23
Neurofibrillary tangle burden	−0.017 (0.008)	.041	−0.022 (0.007)	.003	−0.015 (0.009)	.10

Abbreviations: MT, mid‐temporal cortex; MF, mid‐frontal cortex; AWS, anterior watershed; CR, cerebellum; AD, Alzheimer's disease; CERAD Consortium to Establish a Registry for Alzheimer's Disease; NIA National Institute on Aging; PHF paired helical filaments.

Regression coefficients are reported from multiple logistic regression (for dichotomous outcomes) and multiple linear regression (for continuous outcomes). Continuous outcomes are square root transformed, except for tangle density and neurofibrillary tangle burden, which are quartic root transformed. Models are adjusted for age at death, sex, education, APOE genotype, and post‐mortem interval.

^a n = 317 for analysis of Lewy body due to missing values.