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. 2022 Mar 15;13(16):4490–4497. doi: 10.1039/d2sc00274d

Screening of catalysts for transesterification of methyl 4-nitrobenzoate (5a) with glycidol (GD)a.

graphic file with name d2sc00274d-u1.jpg
Entry Catalyst Loading (mol%) Yield (%)b
1 None 3
2 1-Cl 5 76
3 2-Cl 5 94
4 3-Cl 5 96
5 4-Cl 5 92
6 3-Cl 0.5 90 (87)c
a

Reaction conditions: a mixture of MNB (1.0 mmol), GD (1.2 mmol), and catalyst (5 mol%) in hexane (0.5 mL) was refluxed (heater temp: 80 °C) for 1 hour.

b

Yields were determined by 1H NMR analysis. Values are an average of 2 runs.

c

Yield of the isolated product.