Screening of catalysts for transesterification of methyl 4-nitrobenzoate (5a) with glycidol (GD)a.
| |||
|---|---|---|---|
| Entry | Catalyst | Loading (mol%) | Yield (%)b |
| 1 | None | — | 3 |
| 2 | 1-Cl | 5 | 76 |
| 3 | 2-Cl | 5 | 94 |
| 4 | 3-Cl | 5 | 96 |
| 5 | 4-Cl | 5 | 92 |
| 6 | 3-Cl | 0.5 | 90 (87)c |
Reaction conditions: a mixture of MNB (1.0 mmol), GD (1.2 mmol), and catalyst (5 mol%) in hexane (0.5 mL) was refluxed (heater temp: 80 °C) for 1 hour.
Yields were determined by 1H NMR analysis. Values are an average of 2 runs.
Yield of the isolated product.