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. 2022 Apr 6;13:846124. doi: 10.3389/fendo.2022.846124

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Copyright © 2022 van Roessel, Schouten-van Meeteren, Meijer, Hoving, Bakker and van Santen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prevalence of pituitary disorders (anterior pituitary deficiency, CPP, DI). ACTHD, adrenocorticotropic hormone deficiency; CPP, central precocious puberty; DI, diabetes insipidus; GHD, growth hormone deficiency; TSHD, thyroid-stimulating hormone deficiency. The circles of ACTHD and DI are completely overlapping: every child with ACTHD also had DI. None of the children had LH/FSHD. N = 3 had no pituitary disorder. N = 1 had CPP. N = 1 had CPP and TSHD. N = 1 had GHD and TSHD. N = 1 had TSHD, ACTHD and DI. N = 3 children had GHD, TSHD, ACTHD, and DI.