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. 2022 Apr 6;13:846124. doi: 10.3389/fendo.2022.846124

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Copyright © 2022 van Roessel, Schouten-van Meeteren, Meijer, Hoving, Bakker and van Santen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Longitudinal IGF-1 SDS over time in children with suprasellar LGG presenting with DS. Legend shows patients in correspondence with Table 2 and Figure 2. (A) IGF-1 SDS values over time in all patients. x-axis: age in years at time of measurement, y-axis: IGF-1 SDS corrected for age and gender. (B) IGF-1 SDS values over time for patients with GH hypersecretion only (for 1 patient with GH hypersecretion, data on IGF-1 values over time were missing). (C) BMI SDS (x-axis) according to IGF-1 SDS (y-axis) in all patients. Correlation coefficient for BMI-SDS and IGF-1 SDS: −0.37 (p <0.001). Only IGF-1 values without growth hormone treatment or use of somatostatin analogues are shown.