Table 1.
Top significant CpG probe in the epigenome-wide association study on the epi-cblC phenotype
| CpG probe | Chr | Position* | CpG island | Locus | t-test, P-value | t-test, Bonf. P-value | β-value (Cases) | β-value (Controls) | Δβ-value |
|---|---|---|---|---|---|---|---|---|---|
| cg12630522 | 1 | 45956424 | CpG:51 | TESK2 (promoter) | 3.86E-223 | 1.74E-217 | 0.55 | 0.01 | 0.54 |
| cg19250177 | 1 | 45956646 | CpG:51 | TESK2 (promoter) | 7.56E-204 | 3.42E-198 | 0.46 | 0.01 | 0.45 |
| cg25827112 | 1 | 45956773 | CpG:51 | TESK2 (promoter) | 4.96E-192 | 2.25E-186 | 0.46 | 0.06 | 0.41 |
| cg27633763 | 1 | 45956828 | CpG:51 | TESK2 (promoter) | 1.22E-94 | 5.53E-89 | 0.49 | 0.03 | 0.47 |
| cg19551082 | 1 | 45956882 | CpG:51 | TESK2 (promoter) | 3.62E-148 | 1.64E-142 | 0.32 | 0.06 | 0.27 |
| cg00103132 | 1 | 45956932 | Upstream 5’ end CpG:51 | Upstream 5’ end TESK2 | 4.42E-212 | 2.00E-206 | 0.42 | 0.04 | 0.38 |
| cg00609097 | 1 | 45956974 | Upstream 5’ end CpG:51 | Upstream 5’ end TESK2 | 6.61E-195 | 2.99E-189 | 0.48 | 0.05 | 0.43 |
| cg24296786 | 1 | 45957014 | Upstream 5’ end CpG:51 | Upstream 5’ end TESK2 | 2.75E-199 | 1.24E-193 | 0.53 | 0.05 | 0.48 |
| cg04132845 | 1 | 45957038 | Upstream 5’ end CpG:51 | Upstream 5’ end TESK2 | 1.96E-218 | 8.85E-213 | 0.46 | 0.06 | 0.41 |
| cg15605315 | 1 | 45957053 | Upstream 5’ end CpG:51 | Upstream 5’ end TESK2 | 3.07E-196 | 1.39E-190 | 0.50 | 0.03 | 0.46 |
| cg05765466 | 1 | 45957060 | Upstream 5’ end CpG:51 | Upstream 5’ end TESK2 | 8.34E-203 | 3.77E-197 | 0.46 | 0.08 | 0.38 |
| cg13848568 | 1 | 45965625 | CpG:33 | CCDC163P–MMACHC (bidirectional promoter) | 1.87E-138 | 8.44E-133 | 0.39 | 0.04 | 0.35 |
| cg00081251 | 1 | 45965679 | CpG:33 | CCDC163P–MMACHC (bidirectional promoter) | 2.89E-182 | 1.31E-176 | 0.52 | 0.07 | 0.45 |
| cg09323228 | 1 | 45965727 | CpG:33 | CCDC163P–MMACHC (bidirectional promoter) | 1.18E-171 | 5.33E-166 | 0.49 | 0.05 | 0.44 |
| cg27393325 | 1 | 45965846 | CpG:33 | CCDC163P–MMACHC (bidirectional promoter) | 2.16E-195 | 9.79E-190 | 0.52 | 0.02 | 0.50 |
| cg22536808 | 1 | 45965870 | CpG:33 | CCDC163P–MMACHC (bidirectional promoter) | 7.73E-167 | 3.50E-161 | 0.42 | 0.00 | 0.42 |
| cg14836864 | 1 | 45965990 | CpG:33 | CCDC163P–MMACHC (bidirectional promoter) | 2.33E-167 | 1.05E-161 | 0.43 | 0.03 | 0.40 |
| cg03108114 | 1 | 45966048 | CpG:33 | CCDC163P–MMACHC (bidirectional promoter) | 1.51E-208 | 6.82E-203 | 0.54 | 0.02 | 0.51 |
Chr chromosome; Bonf. Bonferroni; Δβ-value difference between case and control β values
*Genomic positions are reported according to GRCh37