Figure 1.
Novel SHIP1 agonists and their relative activity on SHIP1 and SHIP2
(A) Structures of novel SHIP1 agonists. Percentage increase of phosphatase activity for (B) SHIP1 and (C) SHIP2 enzyme in the malachite green assay. The assay was performed at the indicated mM concentration with the indicated agonist or its vehicle control (0) with 100μM PI(3,4,5)P3-diC8. (Data are representative of 2 independent experiments. Bars indicate mean with ±SEM. The significance of agonism (or inhibition) for each compound vs. vehicle was assessed for all concentration tested via a two-way ANOVA. ∗∗∗∗p < 0.0001, ∗∗∗p < 0.001, ∗p < 0.05).