Table 3.

Relationship between specific IgE levels for lemon seed, orange seed, cashew, pistachio, and Ana o 3.

		Cashew	Pistachio	Ana o 3
All children (n = 103)	Lemon seed	0.9	0.9	0.79
	Orange seed	0.85	0.85	0.75
Children exclusively sensitized to seed storage allergens (n = 51)	Lemon seed	0.97	0.94	0.84
	Orange seed	0.94	0.91	0.84

Sera from 103 children (63 allergic to cashew, 63 allergic to pistachio, 5 with a positive challenge to orange/lemon seeds, and 11 children with a history highly suggestive of orange/lemon seed allergy) were analyzed for sIgE against cashew, pistachio, orange, and lemon seed extracts, and Ana o 3 by ImmunoCAP. Lemon and orange seed-specific IgE levels were found to be highly correlated with IgE levels to cashew and pistachio, with the r ranging from 0.85 to 0.90. After exclusion of sera from children sensitized to pan-allergens (LTP, PR-10, profilin, and CCD/n = 51), the observed correlations were exceedingly high, with r correlation coefficients >0.9, as shown in bold. These data were presented as a poster at The European Academy of Allergy and Clinical Immunology Annual Congress 2014⁸¹, but have not been published in a journal. These data were printed with written permission from Savvatianos et al. CCD, cross-reactive carbohydrate determinants; nsLTP, non-specific lipid transfer protein; PR-10, pathogenesis-related protein type 10