Fig. 6.

L654 significantly attenuates aortic root lesion development in Ldlr^−/− mice. Representative images of ORO-stained aortic roots (A) from Western-type HFD-fed Ldlr^−/− mice injected with vehicle (HFD + Veh) or 1 μg L654 (HFD + L654) every 48 h for 7 weeks. Low-fat chow-fed mice used as a negative control (Chow). Absolute quantification of ORO lesion areas is shown (n = 6–12, mean ± SEM). Statistical significance was determined by two-tailed Student’s t-test between HFD groups (∗P < 0.05). ORO, Oil Red O.