FIG. 5.

Fungal recovery and survival of mice treated with rmGM-CSF. Groups of immunocompetent mice (n = 6) were exposed to 1.25 × 10⁷ organisms and treated with rmGM-CSF or diluent. (A and B) Fungal recovery from lungs (A) and spleens (B). Survival of mice (n = 10) is shown in panel C. (D and E) Fungal burden in lungs (D) and spleens (E) of CD4⁺ CD8⁺ cell-deficient mice (n = 6) challenged with 2.5 × 10⁶ organisms. Survival of mice (n = 10) is illustrated in panel F. Data for fungal burden are expressed as means ± standard errors. The data are pooled results from two independent experiments.